Clavulanic acid production by Streptomyces clavuligerus: biogenesis, regulation and strain improvement
نویسندگان
چکیده
منابع مشابه
An approach to strain improvement and enhanced production of clavulanic acid in Streptomyces clavuligerus.
To develop a strategy for improved production of clavulanic acid (CA), we investigated the effect of using oils on cell growth and CA production during the fermentation of Streptomyces clavuligerus NRRL 3585. In this analysis, triolein, whose fatty acid is oleic acid only, was the best oil source for CA production, but free fatty acids generated from the hydrolysis of oils in a culture broth ne...
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β-lactam antibiotics are among the most popular classes of antibacterial agents, whose mechanism of action consists on the inhibition of bacterial cell wall synthesis.1 The production of β-lactamase is the most important mechanism for bacterial resistance to β-lactam antibiotics.2 Secondary metabolites produced by bacteria exhibit potent biological activities and have been developed extensively...
متن کاملOverproduction of Clavulanic Acid by UV Mutagenesis of Streptomyces clavuligerus
Clavulanic acid is produced industrially by fermentation of Streptomyces clavuligerus and researches have increased its production by strain improvement, recombinant DNA technology, and media composition and growth condition optimization. The main objective of this study was to increase the level of clavulanic acid production from Streptomyces clavuligerus (DSM 738), using UV irradiation. After...
متن کاملOverproduction of Clavulanic Acid by UV Mutagenesis of Streptomyces clavuligerus
Clavulanic acid is produced industrially by fermentation of Streptomyces clavuligerus and researches have increased its production by strain improvement, recombinant DNA technology, and media composition and growth condition optimization. The main objective of this study was to increase the level of clavulanic acid production from Streptomyces clavuligerus (DSM 738), using UV irradiation. After...
متن کاملApplications of gene replacement technology to Streptomyces clavuligerus strain development for clavulanic acid production.
Cephamycin C production was blocked in wild-type cultures of the clavulanic acid-producing organism Streptomyces clavuligerus by targeted disruption of the gene (lat) encoding lysine epsilon-aminotransferase. Specific production of clavulanic acid increased in the lat mutants derived from the wild-type strain by 2- to 2.5-fold. Similar beneficial effects on clavulanic acid production were noted...
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ژورنال
عنوان ژورنال: The Journal of Antibiotics
سال: 2013
ISSN: 0021-8820,1881-1469
DOI: 10.1038/ja.2013.26